Astrobiology is the study of the processes which led to the apparition of life on our planet and which may have or could enable it elsewhere. The LISA research on this topic follows two main paths: studies of the reactivity and evolution of organic matter in extraterrestrial environments and the search for molecular structures through remote sensing and in situ measurements. The LISA thus develops laboratory experiments simulating the conditions of extraterrestrial environments, participates to the designing and building up of chemical analyzers for (mostly ESA and NASA) spatial missions and participates to remote sensing campaigns.